The 27-year-old has only recently returned from a serious knee problem which has sidelined him since August and made just his second start of the season against Fulham last night.
After several years with City, the player chose to stay with the English club at the start of this season but opportunities have proved few and far between and that could force him to seek playing time elsewhere.
"We are sad for him".
Interestingly, De Bruyne will miss the top-of-the-table clash against city rivals Manchester United on November 11, as well as matches against Southampton and West Ham and the reverse fixture against Shakhtar Donetsk in the UEFA Champions League. "Nobody likes to be injured". Yesterday he came back in many things but it is what it is.
"When you come back you can not expect in one day to be the player we know he is, he needs time to settle, take the rhythm, the pace. It is what it is but fortunately it is not surgery and he will be back".More news: India, Korea, US Said to Agree Iran Oil Waiver Outline
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"He knows the desire we want for all young players", said the City manager.
He will definitely be out of City's next two games, against Southampton on Sunday and Shakhtar Donetsk on Wednesday, though he will be helped by the November worldwide break following the derby.
Asked about De Bruyne's injury, Pep Guardiola told a news conference: "He's being checked by the doctors". "We want him, but in the end, it doesn't depend on us".
"He'll spend the time with his new boy and his family".
"He knew that from the beginning and he made a decision to stay".