Most of the jurors questioned at the outset said Guzman's name "sounded familiar" to them.
One of those dismissed was a woman who had written on her questionnaire, "Drugs are bad for you". Those men were tried on home turf, while Guzman was extradited from Mexico in 2017.
Opening arguments are scheduled to start on November 13, after a week of jury selection, held behind closed doors under security reserved for the most risky defendants. Given Guzman's current residence at a high-security prison in Manhattan, Federal agents are scrambling to find ways to transport him to the NYC borough without throwing a wrench in the city's traffic flow. US Marshals will escort them every day.
The 12 jurors, with six alternates, will remain anonymous and once selected, will be partially sequestered.
Mexican druglord "El Chapo" Guzman is on the run from police after making a daring escape from Mexico's most secure prison.
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It is alleged that from 1989 to 2014, the cartel smuggled at least 340,892 pounds (154,626 kilograms) of cocaine into the United States, as well as heroin, methamphetamine and marijuana, raking in $14bn (£11bn). Some are expected to testify under aliases. Even Guzman's lawyers are in the dark as to all the former associates, hired hands or rivals who have turned informants. "No one is going to have pictures of him [Guzman] carrying cocaine, taking the suitcase with money", said Heroy.
There's now speculation that a special cell for Guzman has been set up in the bowels of the courthouse where he will spend the night after his days in court. The only visitors he is allowed are his three lawyers and twin, seven-year-old daughters, from whom he is separated by a thick glass screen.
In a secret meeting with actor Sean Penn which the Hollywood star wrote about in Rolling Stone magazine in 2016, Guzman boasted: "I supply more heroin, methamphetamine, cocaine and marijuana than anybody else in the world".
A query acquired by CNN reads "The case for which you are summoned involves the defendant JOAQUIN ARCHIVALDO GUZMAN LOERA, also known as 'El Chapo.' Have you read, seen or heard anything about the defendant, the case, or people involved?"
He was arrested again by Mexican marines in February 2014 but escaped 14 months later before being re-captured in January 2016. This time, Mexico made a decision to wash their hands and put him on a plane.