Spurs started at lightening pace at the national stadium and needed just eight minutes to go ahead through a Dele Alli header.
Substitute Olivier Giroud added a late consolation for Chelsea but Spurs' win moved them on to 30 points, now two clear of their London rivals.
Here's how we rated the Blues.
"I think it's a mental problem", Sarri said when asked why Chelsea have underwhelmed in recent games.
"We were against a very strong team, especially when they can use very short counter-attacks".
City have now won 12 of their last 13 games with the only dropped points coming in a creditable 0-0 draw at Liverpool last month. We're human. The players and the staff are all disappointed and that's not a good emotion that's going to help you to achieve all that you want. Remember our last season at White Hart Lane. For sure, they will be in the first four positions.
"Frustrating", United manager Jose Mourinho said. The first game after the global break is the highly anticipated derby against Spurs and only three points will keep Chelsea in and around the title race.More news: No. 3 Gonzaga upsets No. 1 Duke for Maui Invitational title
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"We were worse in my era when I was playing, but no-one could record us or take a picture", he said.
Stuart Armstrong grabbed his first Southampton goal after Fulham failed to clear their lines, and the Scotland global was on hand to slot it past Sergio Rico.
Lighting struck twice for Armstrong as he bagged his second Southampton goal after 53 minutes, finding the top corner with a fine effort, before Mitrovic grabbed a brace of his own with a volley at the far post.
Glenn Murray's first goal against Leicester came after 15 minutes, heading the ball on at the near post and beating Kasper Schmeichel.
The fact that a 2-1 win from leaders Borussia Dortmund gets pushed down to the "Elsewhere" portion of our wrap-up shows you the nutty nature of the day.
It was 2-1 to the hosts when Nurnberg went down a man through Robery Bauer's second yellow card.
Gylfi Sigurdsson's effort from six yards was all that separated the sides in a tight game at Goodison Park.