The German was unable to hit through Djokovic, and the world No 1 clinched a 6-3, 6-2, 6-2 victory in just an hour and 33 minutes.
She needs time. But for sure, she will be high because at 18, if you're playing fourth round of a Grand Slam, that means a lot.
After easing into a one-set lead Keys, a semi-finalist here past year encountered some resistance from Siniakova, who however bowed out on her serve when she sent a forehand long.
The last time three teens reached the fourth round at Roland Garros was in 2008.
Tomorrow, play will start at noon.
In the 2012 final against Nadal, he dropped the first two sets before winning the third and was 2-1 up in the fourth when play was suspended until Monday.
Anisimova also explained how she targeted Halep's backhand in her approach to the match.More news: Trump, May, World Leaders To Mark 75th Anniversary Of D-Day Invasion
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"Every match is tough at this level", Halep added. The Frenchman finished with 79 unforced errors.
The Boston Bruins could be without captain Zdeno Chara when they take on the St. Louis Blues in Game 5 of the Stanley Cup Final on Thursday night in Boston. Wimbledon is covered in addition to the Center Court there is now even a second place, the Australian Open in Melbourne even have three stages, where in the case of rain or extreme heat-protected can be played.
Since then, however, the 27-year-old has looked in superb form, dropping four games in her last two matches.
The 64-year-old American was given the award by tournament director Guy Forget and French Tennis Federation president Bernard Giudicelli on Court Philippe Chatrier.
"I have played plenty of, I think, tight matches in my career that I can rely on that experience", the 15-time grand slam victor said.
Keys meets Barty next.
Torrential rain caused a complete washout of quarter-final action at Roland Garros today with Novak Djokovic and Simona Halep amongst the biggest victims.
Before heading out for their match, Anisimova watched Halep play and took notes.